Staphylococcus aureus, the most important human pathogen, produces many enzymes such as penicillinase, beta-lactamase and coagulase that make it be resistant to so many antibiotics. Immunological status of the host, infected site, previous
empirical use
of antibiotics, customs of the community and so many other factors determine the rate of appearance of resistant strains.
The purpose of this study is the evaluation of the sensitivity of S. aureus identified at blood culture for several kinds of antibiotics (Ampicillin, Cephalothin, clindamycin, Chloramphemicol, Erythromycin, Kanamycin, Tetracyclin, Penicillin,
Amikacin,
Methicillin). The results of blood cultures in febrile patients who admitted to Keimyung University Dong-San Medical Center from Jan. 1989 to Jun. 1991 were analyzed and 64 patient with positive blood culture for S. aureus were studied in respect
to
antibiotic sensitivity and clinical aspects.
The results was as follows. Staphylococcus aureus was sensitive to chloramphenicol(92.2%), cephalothin (76.6%), methicillin(70.3%), clindamycin(70.3%), amikacin(64.1%), and erythromycin(59.4%), but to other antimicrobial drugs it showed no
significant
sensitivity.
Methicillin-resistant Staphylococcus aureus(MRSA) was sensitive to chloramphenicol(94.7%), but to other antimicrobial drugs it showed notable drug resistance from 75% to 100%
For under 15 year-old patients, S. aureus was sensitive to chloramphenicol(01.7%), cephalothin(83.3%), clindamycin(83.3%), methicillin(83.3%), amikacin(75%), erythromycin(66.7%), and kanamycin(41.7%).
In comparison of antibiotic sensitivity for S. aureus between patients with and without surgery chlorambhenicol, clindamycin, ampicillin, kanamycin, penicillin and tetracyclin showed no significant difference, but cephalothin, erythromycin,
amikacin and
methicillin exerted better antimicrobial activity for patients without surgery. Chloramphenicol exerted notable antimicrobial activity for patients without surgery(93%) and with surgery(88%).
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